Creating Loaded Meatloaf Casserole is straightforward. Follow these simple steps to prepare this delicious dish:

1. Preheat the oven to 350°F (175°C) and grease a 9×13-inch baking dish.
2. Mix Ingredients: In a large bowl, combine the ground beef, breadcrumbs, shredded cheddar cheese, diced onion, bell peppers, minced garlic, eggs, Worcestershire sauce, salt, black pepper, and Italian seasoning.
3. Form Mixture: Gently mix until everything is evenly combined. Be careful not to overmix, as this can make the meatloaf tough.
4. Add Milk: Stir in the milk until just combined. This will help keep the meatloaf mixture moist.
5. Transfer to Dish: Press the meat mixture into the prepared baking dish, shaping it uniformly.
6. Top with Ketchup: Spread ketchup evenly over the top of the meat mixture for a tasty glaze.
7. Bake: Place the casserole in the preheated oven and bake for 45-50 minutes, or until the meat is no longer pink and reaches an internal temperature of 160°F (70°C).
8. Add Cheese Topping: In the last 10 minutes of baking, sprinkle additional shredded cheese on top. Return to the oven until the cheese is melted and bubbly.
9. Cool and Slice: Remove from the oven and allow the casserole to rest for about 10 minutes before slicing.

Enjoy your incredible Loaded Meatloaf Casserole!